MIO-5381 – Intel Core Ultra Panther Lake 3.5″ SBC by Advantech

The Advantech MIO-5381 is a high-performance 3.5-inch single board computer powered by Intel Core Ultra processors (Panther Lake) with up to 16 cores and 25W TDP. This advanced SBC features dual-channel DDR5-7200 memory supporting up to 128GB with IBECC, integrated NPU delivering up to 50 TOPS for AI workloads, and four independent display outputs via eDP, HDMI, and USB Type-C. Comprehensive connectivity includes dual Ethernet (GbE and 2.5GbE), six USB ports, four COM ports, two CAN-FD interfaces, and four M.2 expansion slots supporting PCIe Gen5. The board supports EdgeBMC for out-of-band management and operates across standard and extended temperature ranges. Available from Recab, your Nordic partner for Advantech embedded computing solutions.

manufacturer

Advantech

product model

MIO-5381
CE Certified, FCC Certified

Overview

The Advantech MIO-5381 represents a cutting-edge 3.5-inch single board computer built on Intel’s latest Core Ultra processor platform, codenamed Panther Lake. Designed for demanding embedded applications requiring exceptional compute performance and AI acceleration, this SBC delivers up to 16 cores with frequencies reaching 4.8 GHz and includes an integrated NPU capable of 50 TOPS for edge AI inference workloads. The platform supports dual-channel DDR5-7200 memory with capacities up to 128GB and features In-Band ECC for enhanced data integrity in mission-critical applications. Display capabilities are comprehensive with support for four simultaneous independent displays through eDP, dual HDMI 2.0, and USB Type-C with DisplayPort Alternate Mode, making it ideal for multi-monitor HMI and digital signage deployments. Networking is handled by Intel i210 and i226 controllers providing GbE and 2.5GbE connectivity respectively. Expansion options are extensive with four standalone M.2 slots including E-Key, B-Key with Nano-SIM support, and dual M-Key slots offering PCIe Gen5 and Gen4 connectivity for high-speed NVMe storage. Additional interfaces include two CAN-FD ports for industrial automation, four COM ports with RS-232/422/485 support, and MIPI-CSI camera inputs. The board incorporates EdgeBMC technology enabling out-of-band remote management and monitoring capabilities essential for distributed deployments. Operating temperature ranges span from standard commercial grades to extended industrial specifications of minus forty to eighty-five degrees Celsius, ensuring reliable operation in challenging environments. Target applications include industrial automation, AI-powered machine vision, medical imaging, transportation systems, and edge computing platforms requiring high-performance processing with comprehensive connectivity. Available from Recab, your Nordic partner for Advantech embedded computing solutions.
AI Accelerated, CAN Bus, Compact, Edge AI Ready, Expandable, Flexible I/O, High Performance, Wide Temperature

Key highlights

Features

  • Intel Core Ultra processors with up to 16 cores and 25W configurable TDP
  • Integrated NPU delivering up to 50 TOPS for AI inference acceleration workloads
  • Dual-channel DDR5-7200 memory support up to 128GB with IBECC protection
  • Four independent display outputs via eDP, dual HDMI, and USB Type-C DP
  • Four M.2 expansion slots with PCIe Gen5 and Gen4 high-speed storage support
  • EdgeBMC out-of-band management for remote monitoring and control capabilities

Specifications

Processor Intel Core Ultra X7/7/5 Processors (Panther Lake)
Max. Frequency Up to 4.8 GHz
Cores/Threads Up to 16 cores
CPU TDP 15W / 25W
Memory DDR5-7200, Dual Channel, Up to 128GB with IBECC
Integrated NPU Up to 50 TOPS
Display Outputs eDP + 2x HDMI 2.0 + 2x USB Type-C (DP Alt. Mode)
Ethernet Intel i210AT/IT (GbE) + Intel i226LM/IT (2.5GbE)
USB 4x USB 3.2 + 6x USB 2.0, 1x USB Type-C
Serial Ports 2x RS-232/422/485
CAN Bus 2x CAN-FD
M.2 Expansion E-Key 2230, B-Key 3052, 2x M-Key 2280 (Gen5/Gen4)
Power Input DC 12V~24V ±10%
Operating Temperature 0~60°C (Standard), -40~85°C (Industrial SKU)
Dimensions 146 x 102 mm (5.7" x 4")

Applications

  • AI-powered edge computing and machine vision systems
  • Industrial automation with CAN-FD communication networks
  • Multi-display digital signage and HMI applications
  • Transportation and vehicle computing platforms

Resources

Datasheet

https://recab.com/wp-content/uploads/2026/09/MIO-5381_DS09172620260917160139.pdf