MIO-5380 – AMD Ryzen AI 3.5″ SBC with NPU by Advantech

The Advantech MIO-5380 is a high-performance 3.5″ single board computer powered by AMD Ryzen AI Embedded P100 Series processors, featuring up to 50 TOPs NPU for AI acceleration. This compact SBC supports dual-channel DDR5-5600 memory up to 128GB with Sideband ECC, four independent displays via eDP, HDMI, and USB Type-C with DP Alt. Mode, and comprehensive connectivity including USB4, 2.5GbE, CAN-FD, and multiple M.2 expansion slots. Extended temperature options from -40°C to 85°C make it ideal for industrial automation, edge AI, and embedded computing applications. Available from Recab, your Nordic partner for Advantech single board computer solutions.

manufacturer

Advantech

product model

MIO-5380
CE Certified, FCC Class B

Overview

The Advantech MIO-5380 represents a significant advancement in 3.5-inch single board computer technology, integrating AMD Ryzen AI Embedded P100 Series processors with up to 12 cores, 24 threads, and maximum frequencies reaching 5.1 GHz. The integrated NPU delivers up to 50 TOPs of AI processing power, making this platform exceptionally suited for edge AI applications, machine vision systems, and intelligent automation deployments. Supporting dual-channel DDR5-5600 memory up to 128GB with Sideband ECC ensures data integrity for mission-critical industrial applications. The MIO-5380 provides extensive display capabilities with four simultaneous independent outputs through eDP 1.4, dual HDMI 2.0b ports supporting 4K resolution at 60Hz, and two USB Type-C ports with DisplayPort Alt. Mode. Networking features include Intel i210 Gigabit Ethernet and Intel i226 2.5GbE with optional Power over Ethernet support. The board offers versatile expansion through four M.2 slots including E-Key for WiFi, B-Key for 4G/LTE modules, and dual M-Key slots for NVMe SSDs with RAID 0/1 support, plus an MCIO connector for additional PCIe connectivity on select SKUs. Industrial-grade features include two CAN-FD interfaces, four COM ports, discrete TPM 2.0, 8-bit GPIO, and comprehensive software API support through iManager 3.0. The EdgeBMC capability enables out-of-band management for remote monitoring and control. With operating temperature ranges from 0°C to 60°C standard and extended options from -40°C to 85°C with industrial SKUs, the MIO-5380 serves demanding environments in factory automation, transportation, medical equipment, and defense applications. Available from Recab, your Nordic partner for Advantech single board computer solutions.
AI Accelerated, CAN Bus, Compact, Edge AI Ready, Expandable, Flexible I/O, High Performance, PoE Supported, Wide Temperature

Key highlights

Features

  • AMD Ryzen AI Embedded P100 processors with up to 50 TOPs NPU for AI acceleration
  • Dual-channel DDR5-5600 memory support up to 128GB with Sideband ECC protection
  • Four independent display outputs via eDP, dual HDMI 2.0b, and USB Type-C DP Alt. Mode
  • USB4 connectivity delivering up to 40Gbps with DisplayPort and PCIe tunneling support
  • Four M.2 expansion slots for WiFi, LTE, and dual NVMe SSDs with RAID support
  • Extended temperature operation from minus 40 to 85 degrees Celsius with industrial SKUs

Specifications

Processor AMD Ryzen AI Embedded P100 Series (P185/P185i/P174/P164/P132/P121)
Core/Thread Up to 12 Cores / 24 Threads
Max. Frequency Up to 5.1 GHz
CPU TDP 28W
Memory DDR5-5600, Dual Channel, Up to 128GB, Sideband ECC
NPU Up to 50 TOPs
Graphics AMD Radeon Graphics, up to 2.9 GHz, 8 Work Group Processors
Display Outputs 1x eDP 1.4, 2x HDMI 2.0b (4K@60Hz), 2x USB Type-C DP Alt. Mode
Ethernet 1x Intel i210 (1GbE), 1x Intel i226 (2.5GbE)
USB 1x USB4 (40Gbps), 1x USB 3.2 Type-C, 2x USB 3.2 Type-A, 2x USB 2.0
COM Ports 1x RS-232/422/485 (8-wire), 3x RS-232 (4-wire)
CAN Bus 2x CAN-FD (2M/4M/8M bit/s) or CAN 2.0 (1M bit/s)
M.2 Slots 1x E-Key 2230, 1x B-Key 3052, 2x M-Key 2280 (PCIe Gen4 x4)
Power Input DC 12V~24V ± 10%
Operating Temperature 0~60°C (Standard), -40~85°C (Extended with Industrial SKU)
Dimensions 146 x 102 mm (5.7" x 4")

Applications

  • Edge AI and machine vision processing in industrial automation systems
  • Intelligent transportation systems requiring multi-display HMI interfaces
  • Medical imaging equipment with high-performance computing requirements
  • Defense and critical infrastructure embedded computing platforms

Resources

Datasheet

https://recab.com/wp-content/uploads/2026/09/MIO-5380_DS08252620260825092813.pdf